A giant snake outside Rockguard. Art by Mike White.
Snakes are carnivorous reptiles from Planet Earth, Mobius and wherever the The Legend of the Golden Axe series takes place in Sonic the Comic. 'Snakes' bring to mind many images in peoples' minds, with certain types famous for injecting their prey with deadly venom, others constrict their foes to death, while there are some that aren't at all dangerous. Ophidiophobia is one of the given names for a fear of snakes. Despite them being one of the world's most feared creatures, many keep them as exotic pets and they are popular characters in fiction.
- Snakes played a major part in Golden Axe story Plague of Serpents. Under the command of Cobraxis and his army of wizard priests, they were used to infiltrate the dwarf stronghold of Rockguard. Several of these, aided by the priests, had hypnotic powers that allowed them to gaze into the victim's eyes before wrapping around their necks and commanding them to fight against their own kind. This tactic worked to differing degrees against Tyris-Flare and Ax-Battler; Tyris was able to close her eyes and swing the Golden Axe, destroying snake and wizard in one swoop. Ax raised his sword in preparation to kill the snake but failed to fight the hypnotism and fell into a trance. The raised sword fell upon the snake and chopped its head off, leaving nobody to command Ax and resulted in him wandering the Hammerynth caverns aimlessly.
Later, more snakes were used as weapon against anyone who dared to challenge Cobraxis. When a spy snake informed Cobraxis that Gilius-Thunderhead and Yuki-Plantcharmer were on their way, the boss sent Viprax to fight them. The understudy first conjured snakes out of rainbow snake dust but, when they were defeated, Viprax turned his own hands into snakes and poisoned the heroes. Later, snakes were turned into a Cage of Snakes to crush Queen Silpantia-Dragontamer and into a snake ball that would tear apart and then latch onto a passing dragon. Finally, large snakes were posted on the outside of Rockguard to ward away intruders. After Cobraxis had transformed himself in the vision of the Serpent God, and was defeated, all remaining snakes were thrown onto a fire and killed.
- Pacifist snakes were seen in Tails story Bite Back, living in a Zone visited by the evil Sleek the Panther. The Doctor Robotnik Appreciation Tribe member attempted to convince the snakes that heroes were weak by defeating the fox and almost convinced them to side with Doctor Robotnik. Even so, the smartly-dressed snakes appeared concerned by Tails' easy defeat and were keen to find out what was wrong with him.
- The villainous Crimson Cobra is a named example of a snake and one of the Chaotix Crew's biggest enemies. Formerly the head of Crimson Cobra Inc. (before Charmy Bee bought it), Cobra managed to turn Vector the Crocodile into a raging beast and turned the other three members insane, believing he had destroyed all his obstacles. The last laugh was on him when baliffs were forced to remove Cobra's mechanical limbs and assistant Cribbins was taken from him by Charmy. Earlier on, Blockhead Bill believed that Sonic the Hedgehog was the Crimson Cobra, despite looking nothing like him.
- One of Brutus' Badniks is a giant cobra on wheels.
- Snakes also look somewhat like worms, another rare species in Sonic the Comic.